Lucky Monroe

There’s an app for that…

Literally an app for everything, however, what’s interesting is I view the body in a very similar way. The body either has adaptabilities in terms of “machinery” to deal with certain inorganic or organic materials. It’s why some people are lactose intolerant and some aren’t. Some individuals have the enzyme lactase that can break down lactose a sugar in many dairy products. Whoever doesn’t? Tough luck eating ice cream, buddy. One of my favorites organics to study is Cannabis. The cool thing about it is, our body’s come built with a cool feature called, the Endocanabinoid system. Think of this system as the hardware to be able to “play the game”. (Btw, you just lost the game)

what-is-the-endocannabinoid-system-3

The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are fat based molecules that originate from within our own bodies. Say it again for the people in the back! WITHIN OUR OWN BODIES! They bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout both our central nervous system (including the brain) and peripheral nervous system.  Believe it or not, this system is involved in much more than just giving people the ability to fly amongst clouds. It’s involved in regulating a variety of physiological and cognitive processes including fertility and pregnancy which I’m extremely interested in. It’s also integral to appetite,  mood, and memory, and in the big one, pain sensation. The ECS is also involved in mediating some of the physiological and cognitive effects of voluntary physical exercise in humans and other animals, such as contributing to exercise-induced euphoria or runner’s high.

Two primary endocannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoids. These two most relevant receptors for cannabinoids are expressed predominantly in the brain and immune system respectively, which is basically our body telling us that if there is an issue with our thinking or our bodily defense mechanism, cannabis can and should probably help.

I encourage you all to do some of your own digging, and make up your own mind about cannabis and its use. This plant has been demonized for so long and as a society that literally shocked it patient’s to death when they were experiencing some kind of psychological disturbance, shouldn’t we be looking for an alternative? Suffering doesn’t and shouldn’t exist when the answers are staring us right in the face. So keep an open mind, will way?

Much love tribe,

xoxo

 

Sources:
  1.  Klein, Carolin; Hill, Matthew N.; Chang, Sabrina C.H.; Hillard, Cecilia J.; Gorzalka, Boris B. (June 2012). “Circulating Endocannabinoid Concentrations and Sexual Arousal in Women”The Journal of Sexual Medicine9 (6). doi:10.1111/j.1743-6109.2012.02708.xISSN 1743-6095PMC 3856894Freely accessiblePMID 22462722.
  2. Wang, Haibin; Xie, Huirong; Dey, Sudhansu K. (June 2006). “Endocannabinoid signaling directs periimplantation events”The AAPS Journal8 (2): E425–E432. doi:10.1007/BF02854916ISSN 1550-7416PMC 3231559Freely accessiblePMID 16808046.
  3. Fride, Ester (1 October 2004). “The endocannabinoid-CB1 receptor system in pre- and postnatal life”European Journal of Pharmacology. SPECIAL CELEBRATORY VOLUME 500 Dedicated to Professor David de Wied Honorary and Founding Editor. 500 (1): 289–297. doi:10.1016/j.ejphar.2004.07.033.
  4. Aizpurua-Olaizola, Oier; Elezgarai, Izaskun; Rico-Barrio, Irantzu; Zarandona, Iratxe; Etxebarria, Nestor; Usobiaga, Aresatz (2016). “Targeting the endocannabinoid system: future therapeutic strategies”Drug Discovery Todaydoi:10.1016/j.drudis.2016.08.005PMID 27554802.
  5. Donvito, Giulia; Nass, Sara R.; Wilkerson, Jenny L.; Curry, Zachary A.; Schurman, Lesley D.; Kinsey, Steven G.; Lichtman, Aron H. (31 August 2017). “The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain”Neuropsychopharmacologydoi:10.1038/npp.2017.204ISSN 1740-634X.
  6. Tantimonaco M, Ceci R, Sabatini S, Catani MV, Rossi A, Gasperi V, Maccarrone M (2014). “Physical activity and the endocannabinoid system: an overview”. Cell. Mol. Life Sci71 (14): 2681–2698. doi:10.1007/s00018-014-1575-6PMID 24526057
  7.  Raichlen DA, Foster AD, Gerdeman GL, Seillier A, Giuffrida A (2012). “Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high'”. J. Exp. Biol215 (Pt 8): 1331–1336. doi:10.1242/jeb.063677PMID 22442371
  8. Thompson, Z., D. Argueta, T. Garland, Jr., and N. DiPatrizio. 2017. Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. Physiology & Behavior 170:141–150.
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